Early Cancer Detection in Primary Care: Are You Aware of New Blood-Based Multi-Cancer Screening Tools A Multimedia eHealth Sourceā„¢ Educational Initiative

Lincoln D. Nadauld, MD, PhD; Charles P. Vega, MD, FAAP

This activity is jointly provided by Global Education Group and Integritas Communications.


This activity is supported by an educational grant from GRAIL.

Target Audience

The educational design of this activity addresses the needs of primary care providers (PCPs), including family and internal medicine physicians, nurse practitioners (NPs), physician assistants (PAs), obstetricians as well as geriatricians involved in early cancer detection.

Program Overview

Despite significant advances in therapy, cancer continues to impose enormous medical, economic, and social burdens. Each year in the United States, approximately 1700 people die from cancer each day, making it the leading cause of mortality in people younger than 80 years old. The costs of treating cancer, including drugs, hospitalization, and ambulatory care, exceed $157 billion annually. Indirect costs, including lost productivity and absenteeism, add nearly another $100 billion to the tally. Early detection is an essential step in reducing the burdens of cancer. Identifying cancer at its earliest stages improves outcomes by allowing therapy to begin sooner, decreasing treatment costs and complexity, reducing morbidity and mortality, and improving quality of life. Liquid biopsy–based multi-cancer early detection (MCED) tests have been developed to support population-based screening of asymptomatic individuals for dozens of cancer types. This multimedia educational activity has been designed to help primary care clinicians—the most important facilitators of preventive healthcare and cancer screening—understand the technology behind MCED tests, interpret data from clinical trials, engage in shared decision-making to determine which patients should be tested, and plan for follow-up examinations in response to a positive test.

Educational Objectives

After completing this activity, the participant should be better able to:

  • Discuss the benefits, limitations, and potential harms of current cancer screening recommendations and protocols
  • Describe recent advances in liquid biopsy approaches including the latest understanding of cell-free DNA for the early detection of multiple cancer types
  • Evaluate recent clinical data on available and emerging non-invasive multi-cancer screening tests and their utility in early cancer detection
  • Design a practical protocol for integration of patient counseling and multi-cancer screening into workflow protocols in the primary care setting


Lincoln D. Nadauld, MD, PhD
Vice President
Chief, Precision Health and Academics
Intermountain Healthcare
St. George, Utah

Charles P. Vega, MD, FAAFP
Clinical Professor, Family Medicine
Director, UC Irvine Program in Medical Education for the Latino Community
Associate Dean, School of Medicine
University of California, Irvine
Irvine, California

Physician Accreditation Statement

This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of Global Education Group (Global) and Integritas Communications. Global is accredited by the ACCME to provide continuing medical education for physicians.

Physician Continuing Medical Education

Global designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Nurse Practitioner Continuing Education

This activity has been planned and implemented in accordance with the Accreditation Standards of the American Association of Nurse Practitioners (AANP) through the joint providership of Global Education Group and Integritas Communications. Global Education Group is accredited by the American Association of Nurse Practitioners as an approved provider of nurse practitioner continuing education. Provider number: 110121. This activity is approved for 1.0 contact hour (which includes 0.0 hours of pharmacology).

Instructions to Receive Credit

In order to receive credit for this activity, the participant must complete the preactivity questionnaire, score 70% or better on the posttest, and complete the program evaluation.

Global Contact Information

For information about the accreditation of this program, please contact Global at 303-395-1782 or

Integritas Contact Information

For all other questions regarding this activity, please contact Integritas via email at

Disclosure of Conflicts of Interest

Global adheres to the policies and guidelines, including the Standards for Integrity and Independence in Accredited CE, set forth to providers by the Accreditation Council for Continuing Medical Education (ACCME) and all other professional organizations, as applicable, stating those activities where continuing education credits are awarded must be balanced, independent, objective, and scientifically rigorous. All persons in a position to control the content of an accredited continuing education program provided by Global are required to disclose all financial relationships with any ineligible company within the past 24 months to Global .  All financial relationships reported are identified as relevant and mitigated by Global in accordance with the Standards for Integrity and Independence in Accredited CE in advance of delivery of the activity to learners. The content of this activity was vetted by Global to assure objectivity and that the activity is free of commercial bias. 

All relevant financial relationships have been mitigated.

The faculty have the following relevant financial relationships with ineligible companies:

Lincoln D. Nadauld, MD, PhD:  Stock Option Holder: Invitae

Charles P. Vega, MD, FAAP:  Consulting Fees: GlaxoSmithKline; Johnson & Johnson

The planners and managers have the following relevant financial relationships with ineligible companies.

Kristin Delisi, NP: Nothing to disclose

Lindsay Borvansky: Nothing to disclose

Andrea Funk: Nothing to disclose

Liddy Knight: Nothing to disclose

Ashley Cann: Nothing to disclose

Jim Kappler, PhD: Nothing to disclose

Disclosure of Unlabeled Use

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA.  Global and Integritas Communications do not recommend the use of any agent outside of the labeled indications.  The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of the planners.  Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.


Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development.  The information presented in this activity is not meant to serve as a guideline for patient management.  Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient's conditions and possible contraindications and/or dangers in use, review of any applicable manufacturer's product information, and comparison with recommendations of other authorities.

Fee Information & Refund/Cancellation Policy

There is no fee for this educational activity.

System Requirements

1.4 GHz Intel Pentium 4 or faster processor (or equivalent)
Windows 10, 8.1 (32-bit/64-bit), Windows 7 (32-bit/64-bit)
512 MB of RAM (1 GB recommended)
Microsoft Internet Explorer 11 or later, Windows Edge browser, Mozilla Firefox, and Google Chrome
For HTML Client – Google Chrome (v70.0 & above), Mozilla Firefox (v65.0 & above), and Edge (v42.0 & above) 

1.83 GHz Intel Core Duo or faster processor
512 MB of RAM (1 GB recommended)
MAC OS X 10.12, 10.13 and 10.14
Mozilla Firefox, Apple Safari, Google Chrome
For HTML Client – Google Chrome (v70.0 & above), Apple Safari (v12.0 & above), and Mozilla Firefox (v65.0 & above) 

Click "Begin Activity" to acknowledge that you have reviewed the preamble information for this activity.

Begin Activity

credit amount 1.00

credit type CME/AANP

release 04/29/2022

expiration 04/29/2023

type eHealthSource