Eric A. Klein, MD
Emeritus Andrew C. Novick Distinguished Chair
Glickman Urological and Kidney Institute
Professor of Surgery, Lerner College of Medicine
Cleveland Clinic
Cleveland, Ohio
Fellow, Distinguished Careers Institute
Stanford University
Stanford, California

John J. Russell, MD, FAAFP
Clinical Professor of Family and Community Medicine
Sidney Kimmel Medical College at Thomas Jefferson University
Chair, Department of Family Medicine
Director, Family Medicine Residency Program
Jefferson Health – Abington
Philadelphia, Pennsylvania

Program Description

Early detection is an essential step in reducing the burdens of cancer. Identifying cancer at its earliest stages improves outcomes by allowing therapy to begin sooner, thereby decreasing treatment costs and complexity, reducing morbidity and mortality, and enhancing quality of life. Although implementation of current screening recommendations has made strides in reducing cancer deaths, there is much room for improvement. Blood-based multi-cancer early detection (MCED) tests have been developed to support population-based screening of asymptomatic individuals for dozens of cancer types. This interactive, multimedia educational activity has been designed to build primary care clinicians' knowledge about the science behind MCED tests, understanding of the evidence behind assay design, interpretation of test results, and ability to implement testing in clinical workflow. Strengthen your endurance as you work out with cases on how to engage in shared decision-making, implement follow-up counseling, and hear about real patients' journeys with MCED testing.

Target Audience

The educational design of this activity addresses the needs of primary care physicians (PCPs), obstetricians, geriatricians, and public health clinicians.

Learning Objectives

After completing this activity, participants will be better prepared to:

  • Recognize the potential of noninvasive MCED tests to increase rates of cancer screening, improve delivery of care, and reduce the burden of disease among various patient groups, including historically underserved populations

  • Review recent scientific advances in liquid biopsy technology, including the latest understanding of cell-free DNA (cfDNA) for the early detection of multiple cancer types

  • Assess current and emerging clinical data on the advantages, disadvantages, accuracy, utility, and cost-effectiveness of available and emerging MCED tests

  • Develop a practical protocol for integrating MCED and patient counseling in the primary care setting

Physician Accreditation Statement

This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of Global Education Group and Integritas Communications. Global Education Group is accredited by the ACCME to provide continuing medical education for physicians.

Physician Credit Designation

Global Education Group designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Nurse Practitioner Continuing Education

This activity has been planned and implemented in accordance with the Accreditation Standards of the American Association of Nurse Practitioners (AANP) through the joint providership of Global Education Group and Integritas Communications. Global Education Group is accredited by the American Association of Nurse Practitioners as an approved provider of nurse practitioner continuing education. Provider number: 110121. This activity is approved for 1.0 contact hour(s) (which includes 0.0 hour(s) of pharmacology).

Disclosure of Conflicts of Interest

Global Education Group adheres to the policies and guidelines, including the Standards for Integrity and Independence in Accredited CE, set forth to providers by the ACCME and all other professional organizations, as applicable, stating those activities where continuing education credits are awarded must be balanced, independent, objective, and scientifically rigorous. All persons in a position to control the content of an accredited continuing education program provided by Global are required to disclose all financial relationships with any ineligible company within the past 24 months to Global. All financial relationships reported are identified as relevant and mitigated by Global in accordance with the Standards for Integrity and Independence in Accredited CE in advance of delivery of the activity to learners. The content of this activity was vetted by Global to assure objectivity and that the activity is free of commercial bias.

All relevant financial relationships have been mitigated.

The faculty have the following relevant financial relationships with ineligible companies:

Eric A. Klein, MD - Consulting fees: Grail

John J. Russell, MD - Nothing to disclose

The planners and managers have the following relevant financial relationships with ineligible companies:

Kristin Delisi, NP: Nothing to disclose
Lindsay Borvansky: Nothing to disclose
Andrea Funk: Nothing to disclose
Liddy Knight: Nothing to disclose
Ashley Cann: Nothing to disclose
Lauren Sinclair: Nothing to disclose
Susan Daniels: Nothing to disclose
Rose O’Connor, PhD, CHCP: Nothing to disclose

Disclosure of Unlabeled Use

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. Global Education Group and Integritas Communications do not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of any organization associated with this activity. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.


Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed in this activity should not be used by clinicians without evaluation of patient conditions and possible contraindications on dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.

Instructions to Receive Credit

In order to receive credit, participants must complete the following:

  1. Read the educational objectives, accreditation information, and faculty disclosures at the beginning of this activity.
  2. Complete the Preactivity Questions.
  3. Review the activity content.
  4. Achieve a grade of 70% on the Postactivity Test Questions and complete the Evaluation.

Fee Information & Refund/Cancellation Policy

There is no fee for this educational activity.

Global Education Group Contact Information

For information about the accreditation of this program, please contact Global Education Group at 303-395-1782 or cme@globaleducationgroup.com.

Begin Activity
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