Cell-free DNA analysis in current cancer clinical trials: a review.
Cisneros-Villanueva M, et al. Br J Cancer. 2022;126(3):391-400.
Projected reductions in absolute cancer–related deaths from diagnosing cancers before metastasis, 2006–2015.
Clarke CA, et al. Cancer Epidemiol Biomarkers Prev. 2020;29(5):895-902.
Circulating tumor DNA (ctDNA) as a pan-cancer screening test: is it finally on the horizon?
Duffy MJ, et al. Clin Chem Lab Med. 2021;59(8):1353-1361.
New genomic technologies for multi-cancer early detection: rethinking the scope of cancer screening.
Hackshaw A, et al. Cancer Cell. 2022;40(2):109-113.
Clinical validation of a targeted methylation-based multi-cancer early detection test using an independent validation set.
Klein EA, et al. Ann Oncol. 2021;32(9):1167-1177.
Sensitive and specific multi-cancer detection and localization using methylation signatures in cell-free DNA.
Liu MC, et al. Ann Oncol. 2020;31(6):745-759.
The PATHFINDER Study: assessment of the implementation of an investigational multi-cancer early detection test into clinical practice.
Nadauld LD, et al. Cancers (Basel). 2021;13(14):3501.
Sensitivity, specificity, and predictive values: foundations, pliabilities, and pitfalls in research and practice.
Trevethan R. Front Public Health. 2017;5:307.
Liquid biopsies come of age: towards implementation of circulating tumour DNA.
Wan JCM, et al. Nat Rev Cancer. 2017;17(4):223-238.
Additional MCED Activities
Top 10 Early Cancer Screening Detection Queries: What You Need to Know About Blood-Based Screening in Primary Care
Multi-Cancer Early Detection in Primary Care: What You Need to Know About New Blood-Based Screening Tools
Flexing Your Early Cancer Detection Muscles: Strengthening Your Knowledge of Blood-Based Screening Tools
Conference Abstracts
Abstracts presented at the American Association for Cancer Research (AACR) 2023 Annual Meeting
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AACR Annual Meeting 2023: Proceedings e-Book
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Proceedings: AACR Annual Meeting 2023; April 14-19, 2023; Orlando, FL; Part 1 (Regular and Invited Abstracts)
Cancer Res. 2023;83(suppl 7).
Abstracts presented at the American Society of Clinical Oncology (ASCO) 2023 Annual Meeting
J Clin Oncol. 2023;41(suppl 16) and 2023;41(suppl 17).
Abstracts presented at the National Comprehensive Cancer Network (NCCN) 2023 Annual Conference
J Natl Compr Canc Netw. 2023;21(3.5).
Guidelines
US Preventive Services Task Force. Published A and B Recommendations for Cancer. Accessed July 13, 2023.
Multicancer Early Detection Consortium. White paper on Multicancer Early Detection (MCED) Screening Guidance: A Recommended Care Pathway for Clinical Use of MCED Tests. June 27, 2023. Accessed July 11, 2023.
Clinician Resources
Prevent Cancer Foundation.
Multi-cancer early detection coverage and legislation.
Surveillance, Epidemiology, and End Results (SEER) *Explorer
An interactive website for SEER cancer statistics. Surveillance Research Program, National Cancer Institute, Division of Cancer Control and Population Sciences.
Galleri Test Website
Menlo Park, CA: Grail LLC.
Hot Topics in Blood-based Cancer Screening
Key Information on Multi-Cancer Early Detection from 2023 Spring Oncology Meetings
Faculty: | Candace T. Westgate, DO, MPH, FACOG; Ethan D. Schram, MD, FACP |
Release: | 08/10/2023 |
Expiration: | 08/10/2024 |