The LGS Journey: Charting the Course Through Critical Decisions in Care

Target Audience

The educational design of this activity addresses the needs of neurology physicians, specialist nurse practitioners (NPs) and physician associates (PAs), neuropsychiatrists, and long-term care providers—including physicians, NPs, and nursing staff—who support adolescents and adults with Lennox-Gastaut (LGS) in residential settings and other chronic care environments.

Program Overview

LGS is a rare, challenging epilepsy disorder that begins in childhood, though diagnosis is often delayed. Developing and tailoring care regimens for patients with LGS is complex and requires careful consideration of antiseizure medication characteristics, patient history and seizure type, comorbidities, and quality of life. Through real-world patient scenarios, learners will examine strategies to recognize LGS in adults, apply evolving evidence to individualized treatment decisions, optimize complex medication regimens, review nonseizure outcomes, and prepare for transition from pediatric to adult care. Dr Scott Perry will provide expert perspective on practical strategies for translating evidence into coordinated patient- and caregiver-centered care. The program also features 3 caregivers, whose perspectives will provide context for real-world challenges commonly seen in LGS.

Educational Objectives 

After completing this activity, the participant should be better able to:

• Identify recognizable genotypic and phenotypic features characteristic of LGS that can aid in diagnosis in adults
• Evaluate the evolving clinical evidence and appropriate use of US Food and Drug Administration–indicated therapies for LGS to support individualized treatment planning
• Optimize pharmacologic regimens by balancing efficacy, tolerability, comorbidities, drug-drug interactions, and appropriate evaluation periods
• Incorporate strategies to assess and manage nonseizure outcomes in patients with LGS

Caregivers

Crystal Ferguson

John Gilmore

Tracy Dixon-Salazar, PhD

Physician Accreditation Statement

Integritas Communications is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

The ANCC’s Commission on Accreditation recognizes educational activities that are approved for AMA PRA Category 1 Credits™ by providers who are accredited by the ACCME to award credit to learners. This reciprocity agreement allows nurses and nurse practitioners to use AMA PRA Category 1 Credits™ as approved ANCC contact hours for license renewal. 

Physician Credit Designation

Integritas designates this enduring activity for a maximum of 1.25 AMA PRA Category 1 Credit™.  Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Disclosures of Relevant Financial Relationships

Integritas adheres to the policies and guidelines, including the Standards for Integrity and Independence in Accredited CE, set forth to providers by the Accreditation Council for Continuing Medical Education (ACCME) and all other professional organizations, as applicable, stating those activities where continuing education credits are awarded must be balanced, independent, objective, and scientifically rigorous. All persons in a position to control the content are required to disclose all financial relationships with any ineligible company within the past 24 months to Integritas.  All financial relationships reported are identified as relevant and mitigated by Integritas in accordance with the Standards for Integrity and Independence in Accredited CE in advance of delivery of the activity to learners. The content of this activity was vetted by Integritas to assure objectivity and that the activity is free of commercial bias.  

All relevant financial relationships have been mitigated. 

The faculty have the following relevant financial relationships with ineligible companies:

M. Scott Perry, MD: 

• Consulting Fees: Biocodex, GenKOre, Neurelis, Orphalan, Servier, Stoke Therapeutics, UCB
• Contracted Research: Encoded Therapeutics, Stoke Therapeutics (both paid to Cook Children’s)
• Ownership Interest: Alto Neurosciences, Biohaven, CAMP4 Therapeutics, Definium Therapeutics, Praxis Precision Medicines, Rapport Therapeutics, Wave Life Sciences
• Unpaid Board Membership: Child Neurology Foundation, Lennox-Gastaut Syndrome Foundation, Pediatric Epilepsy Research Consortium

Caregivers:

• Crystal Ferguson, John Gilmore, and Tracy Dixon-Salazar, PhD have nothing to disclose.

The planners and managers at Integritas Communications have no relevant financial relationships to disclose.

Disclosure of Unlabeled Use

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the US Food and Drug Administration. Integritas Communications does not recommend the use of any agent outside of the labeled indications.  

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of any organization associated with this activity. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

Disclaimer

Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed in this activity should not be used by clinicians without evaluation of patient conditions and possible contraindications or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.

Instructions to Receive Credit

In order to receive credit for this activity, the participant must score 70% on the posttest and complete the program evaluation.

Fee Information & Refund/Cancellation Policy

There is no fee for this educational activity.

Integritas Contact Information

For questions about this activity, please contact Integritas Communications at info@exchangecme.com.