Interactive Exchange

Reducing the Burden of Bipolar Depression

Improved Diagnostic and Management Strategies

Meeting Slides


Mood Disorder Questionnaire

A commonly used, sensitive, and specific screening questionnaire for bipolar disorder. A score of 7 or more across three criteria suggests the presence of bipolar disorder. Hirschfeld RM, et al. Am J Psychiatry. 2000;157:1873-1875.

Bipolar Depression Rating Scale

A rating scale designed to measure the severity of current depressive symptoms in patients with bipolar disorder. The scale contains 20 questions with higher scores indicating greater symptom severity. Berk M, et al. Bipolar Disord. 2007;9:571-579.


Clinical Practice Guidelines for Management of Bipolar Disorder in Adults

Recommendations from the Department of Veterans Affairs for the diagnosis and management of bipolar disorder. The guidelines cover general care and treatment, as well as specific recommendations for older patients. VA/DoD. Clinical Practice Guideline for Management of Bipolar Disorder in Adults. 2010: Washington, DC, Department of Veterans Affairs, Department of Defense.

Diagnostic and Statistical Manual of Mental Disorders (Fifth Edition)

The latest diagnostic guidelines for disorders on the bipolar spectrum from the American Psychiatric Association.
American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders (Fifth edition). 2013: Arlington, VA, American Psychiatric Publishing.

Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) Collaborative Update of CANMAT Guidelines for the Management of Patients With Bipolar Disorder: 2013 Update.

Recommendations for the diagnosis and management of bipolar disorder. The 2013 update contains new evidence for pharmacologic treatment of bipolar depression and specific guidance on the management of bipolar II disorder. Yatham LN, et al. Bipolar Disord. 2013;15:1-44.

Suggested Readings

Sleep and Circadian Rhythms in Bipolar Disorder: Seeking Synchrony, Harmony, and Regulation

Harvey AG. Am J Psychiatry. 2008; 165:820-829.

Clinical Differences Between Bipolar and Unipolar Depression

Forty L, et al. Br J Psychiatry. 2008;19:388-389.

Clinical Practice. Bipolar Disorder—A Focus on Depression

Frye MA. N Engl J Med 2011;364:51-59.

Strategies for Monitoring Outcomes in Patients With Bipolar Disorder

Ketter TA. Prim Care Companion J Clin Psychiatry. 2010;12:10-16.

Clinical Practice Recommendations for Bipolar Disorder

Malhi GS, et al. Acta Psychiatr Scand. 2009;119:27-46

The Canadian Network for Mood and Anxiety Treatments (CANMAT) Task Force Recommendations for the Management of Patients With Mood Disorders and Comorbid Metabolic Disorders.

McIntyre RS, et al. Ann Clin Psychiatry. 2012;24:69-81.

The Neurobiology of the Switch Process in Bipolar Disorder: A Review

Salvadore G, et al. J Clin Psychiatry 2010;71:1488-1501.

An Update on Antidepressant Use in Bipolar Depression

Sidor MM, MacQueen GM. Curr Psychiatry Rep. 2012;14:696-704.

The Functional Neuroanatomy of Bipolar Disorder: A Consensus Model

Strakowski SM, et al. Bipolar Disord. 2012;14:313-325.

Interactive Presentation

Scientific Insights Into Bipolar Disorder and Mood Switching

Terence A. Ketter, MD

Relevant Resources

Improving Outcomes in Bipolar Depression

Overcoming Diagnostic Challenges, Targeting Remission, and Optimizing Cardiometabolic Health

Comprehensive Management of Bipolar Depression

New Approaches to Optimizing Patient Outcomes

A Focus on Bipolar Depression

Overcoming Diagnostic Barriers and Optimizing Long-Term Patient Outcomes

Multidisciplinary Management of Bipolar Disorder

Accelerating Diagnosis, Achieving Remission, and Encouraging Adherence

Mixed Features in Depressive Episodes

Managing Patients Across the Disease Spectrum

Agitation and Psychiatric Disease

Best Practices for Emergency Care

Clinical Issues in Bipolar Depression

Consensus and Controversies Across the Spectrum of Patient Presentations

Expert Consult Series in Multiple Sclerosis

Updates, Clinical Scenarios, and Future Directions