2022 Alzheimer’s disease facts and figures.
Alzheimer’s Association.
The Alzeimer's disease clinical spectrum: diagnosis and management.
Atri A. Med Clin North Am. 2019;103(2):263-293.
Neuropathological stageing of Alzheimer-related changes.
Braak H, Braak E. Acta Neuropathol. 1991;82(4):239-259.
Two randomized phase 3 studies of aducanumab in early Alzheimer's disease.
Budd Haeberlein S, Aisen PS, Barkhof F. et al. J Prev Alzheimers Dis. 2022;9 (2): 197-210.
Costly new Alzheimer disease medications on the horizon—financing alternatives for Medicare.
Fleming WK, Brown CR, Shrank WH. JAMA Health Forum. 2020;1(9):e201148.
Assessment of a plasma amyloid probabilty score to estimate amyloid positron emission tomography findings among adults with cognitive impariment.
Hu Y, Kirmess KM, Meyer MR, et al. JAMA Netw Open. 2022;5(4):e228392.
Pharmacotherapy of Alzheimer's disease: seeking clarity in a time of uncertainty.
Husna Ibrahim N, Yahaya MF, Mohamed W, et al. Front Pharmacol. 2020;11:261.
A/T/N: an unbiased descriptive classification scheme for Alzheimer disease biomarkers.
Jack CR Jr, Bennett DA, Blennow K, et al. Neurology. 2016;87(5):539-547.
Molecular biomarkers of Alzheimer's disease: progress and prospects.
Lashley T, Schott JM, Weston P, et al. Dis Model Mech. 2018;11(5):dmm031781.
Neuroinflammation and microglial activiation in Alzheimer disease: where do we go from here?
Leng F, Edison P. Nat Rev Neurol. 2021;17(3):157-172.
Donanemab in early Alzheimer's disease.
Mintun MA, Lo AC, Duggan Evans C, et al. N Engl J Med. 2021;384(18):1691-1704.
Prediction of future Alzheimer's disease dementia using plasma phospho-tau combined with other accessible measures.
Palmqvist S, Tideman P, Cullen N, et al. Nat Med. 2021;27(6):1034-1042.
Increasing precision of clinical diagnosis of Alzheimer's disease using a combined algorithm incorporating clinical and novel biomarker data.
Sabbagh MN, Lue LF, Fayard D, Shi J. Neurol Ther. 2017;6(suppl 1):83-95.
Amyloid-related imaging abnormalities in 2 phase 3 studies evaluating aducanumab in patients with early Alzheimer disease.
Salloway S, Chalkias S, Barkhof F, et al. JAMA Neurol. 2022;79(1):13-21.
Cognitive assessment of Alzheimer's disease and dementias in clinical practice: pragmatics of brief instruments and neuropsychological evaluation.
Shaughnessy L, Sheard S, Goldfarb D, Atri A. J Clin Psychiatry. 2019;8-(4):MS18002Br2C.
A randomized, double-blind, phase 2b proof-of-concept clinical trial in early Alzheimer's disease with lecanemab, an anti-Aβ protofibril antibody.
Swanson CJ, Zhang Y, Dhadda S, et al. Alzheimers Res Ther. 2021;13(1):80.
What are the difficulties of implementing innovative pharmacy practice models in the care of patients with dementia?
Wimo A. Expert Rev Pharmacoecon Outcomes Res. 2021;21(1):1-4.
Economic burden of Alzheimer disease and managed care considerations.
Wong W. Am J Manag Care. 2020;26(suppl 8):S177-S183.
Clinical Practice Guidelines
The diagnosis of mild cognitive impairment due to Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease.
Albert MS, DeKosky ST, Dickson D, et al. Alzheimers Dement. 2011;7(3):270-279.
The diagnosis of dementia due to Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease.
McKhann GM, Knopman DS, Chertkow H, et al. Alzheimers Dement. 2011;7(3):263-269.
Patient and Caregiver Resources
AD8 dementia screening interview
Alzheimer’s Association
Alzheimer’s Questionnaire
General Practitioner Assessment of Cognition (GPCOG)
Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE)
Mini-Mental State Exam (MMSE) Alzheimer’s / dementia test: administration, accuracy and scoring
Memory Impairment Screen (MIS)
Montreal Cognitive Assessment Test (MoCA) for dementia & Alzheimer’s
Standardized Mini-Cog© Instrument
Clinical Issues in Alzheimer’s Disease
Debates and Discussions About Diagnosis, New Therapies, and Health Care Delivery
Faculty: | Alireza Atri, MD, PhD; Sharon Cohen, MD; Marwan Sabbagh, MD |
Release: | 08/17/2022 |
Expiration: | 08/17/2023 |