Finding the Path in Alzheimer’s Disease
Early Diagnosis to Ongoing Collaborative Care
2020 Alzheimer’s disease facts and figures.
Alzheimer’s Association.
EMERGE and ENGAGE topline results: two phase 3 studies to evaluate aducanumab in patients with early Alzheimer’s disease.
Budd Haeberlein S, von Hehn C, Tian Y, et al. Presented at: 12th Clinical Trials on Alzheimer’s Disease; December 4-7, 2019; San Diego, CA.
Neuroinflammation in Alzheimer’s disease: current evidence and future directions.
Calsolaro V, Edison P. Alzheimers Dement. 2016;12(6):719-732.
Alzheimer’s disease prevention: from risk factors to early intervention.
Crous-Bou M, Minguillón C, Gramunt N, Molinuevo JL. Alzheimers Res Ther. 2017;9(1):71.
A practical algorithm for managing Alzheimer’s disease: what, when, and why?
Cummings JL, Isaacson RS, Schmitt FA, Velting DM. Ann Clin Transl Neurol. 2015;2(3):307-323.
Revising the definition of Alzheimer’s disease: a new lexicon.
Dubois B, Feldman HH, Jacova C, et al. Lancet Neurol. 2010;9(11):1118-1127.
Update on Alzheimer’s disease therapy and prevention strategies.
Graham WV, Bonito-Oliva A, Sakmar TP. Annu Rev Med. 2017;68:413-430.
Alzheimer’s disease: the amyloid cascade hypothesis.
Hardy JA, Higgins GA. Science. 1992;256(5054):184-185.
Alzheimer’s disease: the amyloid hypothesis on trial.
Harrison JR, Owen MJ. Br J Psychiatry. 2016;208(1):1-3.
Tracking pathophysiological processes in Alzheimer’s disease: an updated hypothetical model of dynamic biomarkers.
Jack CR Jr, Knopman DS, Jagust WJ, et al. Lancet Neurol. 2013;12(2):207-216.
A/T/N: an unbiased descriptive classification scheme for Alzheimer disease biomarkers.
Jack CR Jr, Bennett DA, Blennow K, et al. Neurology. 2016;87(5):539-547.
Molecular and cellular basis of neurodegeneration in Alzheimer’s disease.
Jeong S. Mol Cells. 2017;40(9):613-620.
Cognitive symptoms of Alzheimer’s disease: clinical management and prevention.
Joe E, Ringman JM. BMJ. 2019;367:l6217.
The diagnosis and management of mild cognitive impairment: a clinical review.
Langa KM, Levine DA. JAMA. 2014;312(23):2551-2561.
Exercise is associated with reduced risk for incident dementia among persons 65 years of age and older.
Larson EB, Wang L, Bowen JD, et al. Ann Intern Med. 2006;144(2):73-81.
A critical appraisal of amyloid-β-targeting therapies for Alzheimer disease.
Panza F, Lozupone M, Logroscino G, Imbimbo BP. Nat Rev Neurol. 2019;15(2):73-88.
The amyloid hypothesis of Alzheimer’s disease at 25 years.
Selkoe DJ, Hardy J. EMBO Mol Med. 2016;8(6):595-608.
Treatment of early AD subjects with BAN2401, an anti-Aβ protofibril monoclonal antibody, significantly clears amyloid plaque and reduces clinical decline.
Swanson CJ, Zhang Y, Dhadda S, et al. Alzheimers Dement. 2018;14(suppl 7):P1668-P1668.
Potential new approaches for diagnosis of Alzheimer’s disease and related dementias.
Turner RS, Stubbs T, Davies DA, Albensi BC. Front Neurol. 2020;11:496.
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Clinical Practice Guidelines
The diagnosis of mild cognitive impairment due to Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease.
Albert MS, DeKosky ST, Dickson D, et al. Alzheimers Dement. 2011;7(3):270-279.
The diagnosis of dementia due to Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease.
McKhann GM, Knopman DS, Chertkow H, et al. Alzheimers Dement. 2011;7(3):263-269.
Practice guideline update summary: mild cognitive impairment: report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology.
Petersen RC, Lopez O, Armstrong MJ, et al. Neurology. 2018;90(3):126-135.
Patient and Caregiver Resources
AD8 dementia screening interview
Alzheimer’s Association
Alzheimer’s Disease Education and Referral (ADEAR) Center
Family Caregiver Alliance
General Practitioner Assessment of Cognition (GPCOG) Informant Questionnaire on Cognitive Decline in the Elderly (IQ-CODE) Mini-Mental State Exam (MMSE) Alzheimer’s / dementia test: administration, accuracy and scoring Memory Impairment Screen (MIS)
Montreal Cognitive Assessment Test (MoCA) for dementia & Alzheimer’s
Standardized Mini-Cog© Instrument
Finding the Path in Alzheimer’s Disease
Early Diagnosis to Ongoing Collaborative Care
| Faculty: | Sharon Cohen, MD, FRCPC; R. Scott Turner, MD, PhD |
| Release: | 11/20/2020 |
| Expiration: | 11/20/2021 |
