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Clinical Research Updates

Putting a Spotlight on Systemic Mastocytosis

A Multidisciplinary Look at Early Diagnosis and Management

Clinical Practice Guidelines

The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia.

Arber DA, Orazi A, Hasserjian R, et al. Blood. 2016;127(20):2391-2405.

NCCN Clinical Practice Guidelines in Oncology: Systemic Mastocytosis.

National Comprehensive Cancer Network.

Patient Resources

The Mast Cell Disease Society, Inc. (TMS)

TMS is dedicated to providing multifaceted support to patients, families, and medical professionals in the community and to leading the advancement of knowledge and research in mast cell diseases through education, advocacy, and collaboration.

The European Competence Network on Mastocytosis (ECNM)

The goal of the ECNM is to improve disease-recognition, diagnosis, and therapy in patients with mastocytosis in Europe.

Suggested Readings

Results from Pioneer: a randomized, double-blind, placebo-controlled, phase 2 study of avapritinib in patients with indolent systemic mastocytosis.

Akin C, Elberink HO, Gotlib J, et al. American Society of Hematology Virtual Conference; December 5-8, 2020. Abstract 1248.

Update on mastocytosis (part 1): pathophysiology, clinical features, and diagnosis.

Azaña JM, Torrelo A, Matito A. Actas Dermosifiliogr. 2016;107(1):5-14.

Patients with mast cell activation symptoms and elevated baseline serum tryptase level have unique bone marrow morphology.

Giannetti MP, Akin C, Hufdhi R, et al. J Allergy Clin Immunol. 2021;147(4):1497-1501.e1491.

Catching the clinical and biological diversity for an appropriate therapeutic approach in systemic mastocytosis.

Mannelli F. Ann Hematol. 2021;100(2):337-344.

Systemic mastocytosis in adults: 2021 Update on diagnosis, risk stratification and management.

Pardanani A. Am J Hematol. 2021;96(4):508-525. 

How we diagnose and treat systemic mastocytosis in adults.

Scherber RM, Borate U. Br J Haematol. 2018;180(1):11-23.

Mast cells, mastocytosis, and related disorders.

Theoharides TC, Valent P, Akin C. N Engl J Med 2015;373(2):163-172.

Mastocytosis: lessons learned from the 2019 Society for Hematopathology/European Association for Haematopathology Workshop.

Tzankov A, Duncavage E, Craig FE, et al. Am J Clin Pathol. 2021;155(2):239-266.

Clinical features and survival of patients with indolent systemic mastocytosis defined by the updated WHO classification.

Trizuljak J, Sperr WR, Nekvindova L, et al. Allergy. 2020;75(8):1923-1934.

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Putting a Spotlight on Systemic Mastocytosis

A Multidisciplinary Look at Early Diagnosis and Management

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