An Expert Panel on Severe Asthma
From the Epithelium to Better Patient Outcomes
Burdens of Severe Asthma: A Patient's Perspective
Understanding asthma phenotypes, endotypes, and mechanisms of disease.
Kuruvilla ME, et al. Clin Rev Allergy Immunol. 2019;56(2): 219-233.-233.
Oral corticosteroid exposure and adverse effects in asthmatic patients.
Sullivan PW, et al. J Allergy Clin Immunol. 2018;141(1):110-116.e7.
Mucus plugs persist in asthma, and changes in mucus plugs associate with changes in airflow over time.
Tang M, et al. Am J Respir Crit Care Med. 2022;205(9):1036-1045.
Effect of biologic therapies on airway hyperresponsiveness and allergic response: a systematic literature review.
Spahn JD, et al. J Asthma Allergy. 2023;16:755-774.
Efficacy of biologic therapy on airway hyperresponsiveness in asthma.
Chan R, Lipworth B. Ann Allergy Asthma Immunol. 2023;131(1):37-41.
Evaluating the effect of dupilumab on type 2 airway inflammation and mucus plugging in patients with uncontrolled moderate-to-severe asthma: the VESTIGE trial.
Castro M, et al. J Allergy Clin Immunol. 2024;153(2):AB368.
The effect of tezepelumab on airway hyperresponsiveness to mannitol in asthma (UPSTREAM).
Sverrild A, et al. Eur Respir J. 2022;59(1):2101296.
Tezepelumab and mucus plugs in patients with moderate-to-severe asthma.
Nordenmark LH. NEJM Evid. 2023;2(10).
T2-“low” asthma: overview and management strategies.
Fitzpatrick AM, et al. J Allergy Clin Immunol Pract. 2020;8(2):452-463.
Treatment options in type-2 low asthma.
Hinks TSC, et al. Eur Respir J. 2021;57(1):2000528.
Patient Advocacy Organizations and Resources
Asthma and Allergy Foundation of America (AAFA)
AAFA is dedicated to improving the quality of life for people with asthma and allergic diseases through education, advocacy, and research.
American College of Allergy, Asthma & Immunology (ACAAI)
The ACAAI fosters a culture of collaboration and congeniality in which members work toward the common goals of patient care, education, advocacy, and research.
American Lung Association
The American Lung Association is a leading organization working to save lives by improving lung health and preventing lung disease through education, advocacy, and research.
American Thoracic Society (ATS)
ATS is dedicated to accelerating the advancement of global respiratory health through multidisciplinary collaboration, education, and advocacy.
Chest Foundation
The CHEST Foundation creates trusted patient education resources and disease awareness campaigns that empower patients to engage in better managing their health.
Clinical Practice Guidelines
Global Strategy for Asthma Management and Prevention.
Global Initiative for Asthma, 2024.
Management of severe asthma: a European Respiratory Society/American Thoracic Society guideline.
Holguin F, et al. Eur Respir J. 2020;55(1):1900588.
Clinical Practice Tools
Centers for Disease Control and Prevention (CDC) Asthma Action Plans
These tools for asthma control were created following the evidence-based guidance published by the National Institutes of Health.
Asthma Control Test (ACT)
This 5-question test evaluates asthma control over the past 4 weeks on a 5-point Likert scale. A score of <20 on the ACT suggests asthma that is uncontrolled.
Nathan RA, et al. J Allergy Clin Immunol. 2004;113(1):59-65.
Asthma Control Questionnaire (ACQ)
This 7-question assessment tool measures asthma control over the past 7 days. Six questions are self-administered by the patient, and 1 question requires a clinician’s input. Scores range from 1 (totally controlled) to 6 (severely uncontrolled).
Juniper EF, et al. Eur Respir J. 1999;14(4):902-907.
Asthma Therapy Assessment Questionnaire (ATAQ)
This 4-question test assesses asthma control over the past 4 weeks. Each question has a possible score of 0 or 1; if the sum of the 4 question scores is >1, the patient’s asthma may be uncontrolled.
Vollmer WM, et al. Am J Respir Crit Care Med. 1999;160(5 Pt 1):1647-1652.
An Expert Panel on Severe Asthma
From the Epithelium to Better Patient Outcomes
| Faculty: | Geoffrey Chupp, MD; Njira Lucia Lugogo, MD, MS; Michael E. Wechsler, MD, MMSc |
| Release: | 05/22/2024 |
| Expiration: | 06/22/2024 |
An Expert Panel on Severe Asthma
From the Epithelium to Better Patient Outcomes
| Faculty: | Geoffrey Chupp, MD; Njira Lucia Lugogo, MD, MS; Michael E. Wechsler, MD, MMSc |
| Release: | 06/06/2024 |
| Expiration: | 06/06/2025 |
