Dupilumab Efficacy and Safety in Children with Uncontrolled, Moderate-to-Severe Asthma: The Phase 3 VOYAGE Study.
Bacharier LB, et al. ATS 2021. Abstract A1204.
Dupilumab Efficacy and Safety in Moderate-to-Severe Uncontrolled Asthma.
Castro M, et al. N Engl J Med. 2018;378(26):2486-2496
New targeted therapies for uncontrolled asthma.
Corren J. J Allergy Clin Immunol Pract. 2019;7(5):1394-1403
Predictors of enhanced response with benralizumab for patients with severe asthma: pooled analysis of the SIROCCO and CALIMA studies.
FitzGerald JM, et al. Lancet Respir Med. 2018;6(1):51-64.
Long-term safety and pharmacodynamics of mepolizumab in children with severe asthma with an eosinophilic phenotype.
Gupta A, et al. J Allergy Clin Immunol. 2019;144(5):1336-1342.e7.
Understanding asthma phenotypes, endotypes, and mechanisms of disease.
Kuruvilla ME, et al. Clin Rev Allergy Immunol. 2019;56(2):219-233.-233.
Omalizumab for the treatment of exacerbations in children with inadequately controlled allergic (IgE-mediated) asthma.
Lanier B, et al. J Allergy Clin Immunol. 2009;124(6):1210-1216.
Elimination of oral corticosteroids (OCS) with benralizumab treatment in OCS-dependent asthmatics using a rapid, personalized algorithm: the PONENTE trial.
Menzies-Gow A, et al. J Allergy Clin Immunol. 2021;147(2):AB249.
Oral corticosteroid exposure and adverse effects in asthmatic patients.
Sullivan PW, et al. J Allergy Clin Immunol. 2018;141(1):110-116.e7.
Clinical Practice Guidelines
Global Strategy for Asthma Management and Prevention.
Global Initiative for Asthma, 2021.
Difficult-to-Treat & Severe Asthma in Adolescent and Adult Patients: Diagnosis and Management.
Global Initiative for Asthma, 2021.
Management of severe asthma: a European Respiratory Society/American Thoracic Society guideline.
Holguin F, et al. Eur Respir J. 2020;55(1):1900588.
National Asthma Education and Prevention Program. Expert Panel Report 3: Guidelines for the Diagnosis and Management of Asthma – Summary Report 2007.
Clinical Practice Tools
Centers for Disease Control and Prevention (CDC) Asthma Action Plans
These tools for asthma control were created following the evidence-based guidance published by the National Institutes of Health.
Asthma Control Test (ACT) and Childhood Asthma Control Test (C-ACT)
Both versions of this 5-question test evaluate asthma control over the past 4 weeks on a 5-point Likert scale. A score of <20 on either ACT suggests asthma that is uncontrolled; the C-ACT is for children 4 to 11 years of age.
Nathan RA, et al. J Allergy Clin Immunol. 2004;113(1):59-65.
Asthma Control Questionnaire (ACQ)
This 7-question assessment tool measures asthma control over the past 7 days. Six questions are self-administered by the patient, and 1 question requires a clinician’s input. Scores range from 1 (totally controlled) to 6 (severely uncontrolled).
Juniper EF, et al. Eur Respir J.1999;14(4):902-907.
TRACK (Test for Respiratory and Asthma Control in Kids)
A 5-question test to assess respiratory and asthma control in patients between the ages of 12 months and 5 years. To be used by caregivers and interpreted by clinicians. If children score <80, their breathing problems may not be under control.
Murphy KR, et al. J Allergy Clin Immunol. 2009;123(4):833-839.
Patient Advocacy Organizations and Resources
Asthma and Allergy Foundation of America (AAFA)
AAFA is dedicated to improving the quality of life for people with asthma and allergic diseases through education, advocacy, and research.
American College of Allergy, Asthma & Immunology (ACAAI)
The ACAAI fosters a culture of collaboration and congeniality in which members work toward the common goals of patient care, education, advocacy, and research.
American Lung Association
The American Lung Association is the leading organization working to save lives by improving lung health and preventing lung disease through education, advocacy, and research.
American Thoracic Society (ATS)
The mission of the ATS is to improve health worldwide by advancing research, clinical care, and public health in respiratory disease, critical illness, and sleep disorders.
Chest Foundation
The CHEST Foundation creates trusted patient education resources and disease awareness campaigns that empower patients to engage in better managing their health.
Test Your Might in Pediatric Asthma
Module 1
Faculty: | Wanda Phipatanakul, MD, MS; Michael E. Wechsler, MD, MMSc |
Release: | 10/07/2021 |
Expiration: | 10/07/2022 |
A Patient Simulation
Module 2
Faculty: | Wanda Phipatanakul, MD, MS; Michael E. Wechsler, MD, MMSc |
Release: | 10/07/2021 |
Expiration: | 10/07/2022 |
Exercising Best Practices in Pediatric Asthma
Module 3
Faculty: | Wanda Phipatanakul, MD, MS; Michael E. Wechsler, MD, MMSc |
Release: | 12/03/2021 |
Expiration: | 12/03/2022 |