Clinical Research Updates™

Clinical Updates in Rheumatoid Arthritis

Evolving Treatment Algorithms and Expert Perspectives on Biosimilars

Clinical Practice Guidelines

2015 American College of Rheumatology Guidelines for the Treatment of Rheumatoid Arthritis.

Singh JA, et al. Arthritis Rheumatol. 2016;68(1):1-26.

EULAR Recommendations for the Management of Rheumatoid Arthritis With Synthetic and Biological Disease-Modifying Antirheumatic Drugs: 2013 Update

Smolen JS, et al. Ann Rheum Dis. 2014;73(3):492-509.

Treating Rheumatoid Arthritis to Target: 2014 Update of the Recommendations of an International Task Force

Smolen JS, et al. Ann Rheum Dis. 2016;75(1):3-15

Patient Resources

American College of Rheumatology

The American College of Rheumatology provides information for patients and caregivers that covers a breadth of topics, including the effects of rheumatoid arthritis (RA), importance of early treatment, access to biologic medications, patient advocacy, and more

Arthritis Foundation

The Arthritis Foundation provides self-care tools and resources covering treatment options, pain management, diet and exercise, and common comorbidities associated with RA.

NIAMS Handout on Health: Rheumatoid Arthritis

This National Institute of Arthritis and Musculoskeletal and Skin Diseases publication is a resource for patients and their families that describes how RA develops, how it is diagnosed, and how it is treated. It also highlights current research efforts and addresses what people can do to help self-manage their disease.

Rheumatoid Arthritis Support Network

The Rheumatoid Arthritis Support Network is dedicated to providing up-to-date information and resources for patients with RA.

Clinical Assessment Tools

American College of Rheumatology Disease Activity and Functional Status Assessment Online Calculators

The American College of Rheumatology has endorsed several RA disease activity measures, formatted as online calculators, to facilitate clinical decision-making.

Clinical Disease Activity Index (CDAI)

The CDAI for RA is a validated instrument that has providers survey 28 joints, the results of which are integrated with the patient’s and clinician’s global health assessment (Aletaha D, et al. Arthritis Res Ther. 2005;7(4):R796-R806).

Disease Activity Score (DAS28)

The DAS28 is a measure of RA disease activity that combines an assessment of 28 joints, results from laboratory testing (DAS28-ESR or DAS28-CRP), and a visual analog scale (Van Der Heijde DMFM, et al. J Rheumatol. 1993;20(3):579-581; Van Gestel AM, et al. Arthritis Rheum. 1998;41(10):1845-1850).

Routine Assessment of Patient Index Data 3 (RAPID3)

RAPID3 is a pooled index of the 3 patient-reported measures from the ACR Core Data Set for RA: function, pain, and patient global estimate of status (Pincus T, et al. Rheum Dis Clin North Am. 2009;35(4):773-778).

Simplified Disease Activity Index (SDAI)

Similar to the CDAI, the SDAI for RA has providers survey 28 joints, incorporates the patient’s and clinician’s global health assessment, and includes the circulating level of C-reactive protein (Smolen JS, et al. Rheumatol. 2003;42(2):244-257).

Suggested Readings

American College of Rheumatology Annual Meeting Abstract Archives

2016 Annual Meeting held in Washington, DC, November 11-16, 2016.

American College of Rheumatology Position Statement on Biosimilars

American College of Rheumatology. Released April 2016.

Annual European Congress of Rheumatology 2016 Abstracts

Hosted by the European League Against Rheumatism (EULAR) in London, England, June 14-17, 2016.

Understanding the dynamics: pathways involved in the pathogenesis of rheumatoid arthritis

Choy E. Rheumatology (Oxford). 2012;51(suppl 5):v3-v11.

Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part I.

Helmick CG, et al. Arthritis Rheum. 2008;58(1):15-25.

Safety and efficacy of biological disease-modifying antirheumatic drugs in older rheumatoid arthritis patients: staying the distance.

Ishchenko A, Lories RJ. Drugs Aging. 2016;33(6):387-398.

Cardiovascular risk and the use of biologic agents in rheumatoid arthritis.

Lim DT, et al. Curr Rheumatol Rep. 2014;16(11):459. 2012;130(2):332-342.e10.

Study of active controlled tocilizumab monotherapy for rheumatoid arthritis patients with an inadequate response to methotrexate (SATORI): significant reduction in disease activity and serum vascular endothelial growth factor by IL-6 receptor inhibition therapy.

Nishimoto N, et al. Mod Rheumatol. 2009;19(1):12-19.

Tocilizumab monotherapy versus adalimumab monotherapy for treatment of rheumatoid arthritis (ADACTA): a randomised, double-blind, controlled phase 4 trial.

Gabay C, et al. Lancet. 2013;4:381(9877):1541-1550.

Preclinical lung disease in early rheumatoid arthritis.

Robles-Perez A, et al. Chron Respir Dis. 2016;13(1):75-81.

The pathogenesis of rheumatoid arthritis: new insights from old clinical data?

Smolen JS, et al. Nat Rev Rheumatol. 2012;8(4):235-243

Discontinuation of adalimumab after achieving remission in patients with established rheumatoid arthritis: 1-year outcome of the HONOR study.

Tanaka Y, et al. Ann Rheum Dis. 2015;74(2):389-395.

Mortality in rheumatoid arthritis. Increased in the early course of disease, in ischaemic heart disease and in pulmonary fibrosis

Young A, et al. Rheumatology (Oxford). 2007;46(2):350-357

Interactive Presentation

Clinical Updates in Rheumatoid Arthritis

Howard Blumstein, MD; Allan Gibofsky, MD, JD; Jonathan Kay, MD

Clinical Updates in Rheumatoid Arthritis

Evolving Treatment Algorithms and Expert Perspectives on Biosimilars

Relevant Resources

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Improved Diagnostic and Management Strategies

Advances in Immunosupressive Therapy for Solid Organ Transplantation

Long-Term Management Strategies to Improve Patient Outcomes

Acute Management of Migraine Attacks

Overcoming Pain and Gastrointestinal Distress to Improve Patient Outcomes

Clinical Updates on the Management of Gout

Evidence-Based Strategies for Improved Patient Outcomes

Opioid-Induced Constipation

Proactive Diagnosis and Targeted Management

Chronic Obstructive Pulmonary Disease, Asthma, or Both

Differential Diagnosis and Comprehensive Management Strategies

Improving Outcomes in Chronic Obstructive Pulmonary Disease

Optimizing Maintenance Therapy Across Healthcare Settings

Managing Gout in Primary Care

Evolving Strategies for Diagnosis and Long-Term Management

Clinical Issues in Chronic Pain

Consensus and Controversies for Responsible Opioid Prescribing

Noninsulin Approaches to Managing Type 2 Diabetes

Best Practices in Combination Therapy

Hitting the Target in Type 2 Diabetes

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Improving Outcomes in Rheumatoid Arthritis

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Clearing the Air

Improving Outcomes for Patients with COPD

Clinical Updates in Type 2 Diabetes

New Strategies for Insulin Replacement Therapy

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Clinical Updates in LDL-C Management

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Improving Comprehensive Patient Care

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Identifying Patients and Tailoring Therapy

Comprehensive Management of Chronic Obstructive Pulmonary Disease

Collaborative Approaches to Guideline-Concordant Patient Care

Clinical Updates in the Management of Severe Asthma

New Strategies for Individualizing Long-term Care

Comprehensive Chronic Pain Management

A Focus on Patients With Opioid-Induced Constipation

Clinical Issues in Bipolar Depression

Consensus and Controversies Across the Spectrum of Patient Presentations

Going Deeper on Atopic Dermatitis

Pathophysiology to the Management of Moderate-to-Severe Disease

Caring for Patients with Severe Asthma

Evolving Best Practices to Optimize Outcomes

Looking Beneath The Surface In Atopic Dermatitis

Targeting Immune Dysregulation and Delivering Comprehensive Care

Can You Spot Axial Spondyloarthritis?

The PCP’s Role in Timely Recognition and Referral

Evolving Treatment Paradigms For Rheumatoid Arthritis

Translating Comprehensive Patient Evaluations Into Personalized Therapy

Clinical Updates in Rheumatoid Arthritis

New Perspectives on Targeting Remission and Individualizing Therapy

A Better Look at Rheumatoid Arthritis

Using Imaging to Improve Patient Outcomes

Clinical Issues in Rheumatoid Arthritis

Discussions and Debates on the Evolving Roles of Targeted Synthetic DMARDs

Advancing the Care of Severe Asthma

Differential Diagnosis, Multidisciplinary Management, and Patient Engagement

Updates in HCV Screening and Treatment

Key Issues Impacting OB/GYN Practice

Pathways to Better Outcomes in Systemic Lupus Erythematosus

Translating Pathophysiology into Targeted Treatments

The Big Picture of IBD

An Interactive Experience Highlighting Recent Clinical Advances

Evolving Models of HIV Care

Volume II: Expanding Evidence for the Role of Rapid ART Initiation in HIV Practice

Clinical Issues in Rheumatoid Arthritis

Debates & Discussions on the Evolving Role of JAK Inhibitors

Clearing the Air in Severe Asthma Management

Improving Patient Outcomes Through Shared Clinical Decision Making

GLP-1 Receptors Agonists in Type 2 Diabetes

Mechanistic Insights and Evolving Treatment Options

Clinical Issues in Rheumatoid Arthritis

The Evolving Role of JAK Inhibitors

JAKi in RA Practice

Unpacking the Evidence for Their Use Today and Tomorrow

Airing It Out

A Case-Based Conversation on Managing Asthma and Chronic Rhinosinusitis With Nasal Polyposis

COPD in Managed Care

The Clinical and Utilization Benefits of Exacerbation Prevention

Assimilating the Evidence in T2DM

Cardiovascular and Renal Outcomes With SGLT2 Inhibitors

Demystifying New Evidence for COPD Management

Best Practices for Primary Care

Finding Relief in Osteoarthritis

New Paths to Chronic Pain Management

The Changing Landscape of HIV Prevention

What the Pharmacist Needs to Know about PrEP

What’s New in Systemic Lupus Erythematosus?

Unlocking Novel Paths to Patient Care

Expert Views on the Changing Landscape in RA

The Increasing Role of JAK Inhibitors

Updates in Systemic Lupus Erythematosus

Unlocking Novel Paths to Patient Care

Swimming Upstream in Severe Asthma

New Pathways to Patient Management

Optimizing Advanced Therapies in Ulcerative Colitis: Is Your Practice Up to Date?

A Focus on Clinical Evidence and Guideline Recommendations

COPD Cases & Conversations

Preventing COPD Exacerbations to Improve Outcomes

Comprehensive Management in COPD

A Whole Patient Case Series

Cause for Alarm

New Avenues to the Management of Severe Asthma

Maybe It’s NOT Mechanical Back Pain

Getting on the Fast Track to Identify AxSpA

Treating Hepatitis C in the Primary Care Setting

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Finding the Path in Eosinophilic Esophagitis

Interdisciplinary Strategies for Adult and Pediatric Patients

Answering the Call

Interdisciplinary Management of Eosinophilic Esophagitis and Hereditary Angioedema

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Expert Consult Series in Multiple Sclerosis

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Putting a Spotlight on Systemic Mastocytosis

A Multidisciplinary Look at Early Diagnosis and Management

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Is It Systemic Mastocytosis?

Best Practices for Diagnosis and Management

Monoclonal Antibodies for COVID-19

An Update on Best Practices

Monoclonal Antibodies for COVID-19

New Avenues to Pre-Exposure Prophylaxis

Early Cancer Detection in Primary Care:

Are You Aware of New Blood-Based Multi-Cancer Screening Tools

Choosing Your Path in Systemic Lupus Erythematosus

From Patient Evaluations to New Targeted Therapies

Buffing Up on New and Emerging ART

A Look at the Changing HIV Playing Field

Pharmacy PrEP Education

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Building Bridges to Reach People who Inject Drugs with the Goal of Employing PrEP for HIV Prevention

Flexing Your Early Cancer Detection Muscles

Strengthening Your Knowledge of Blood-Based Screening Tools

Long-Acting Injectable PrEP:

Bringing HIV Prevention to a New Level

PrEParing to End the Epidemic

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Multi-Cancer Early Detection in Primary Care

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Anemia in Chronic Kidney Disease

New Avenues to Improve Patient Outcomes

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Best Practices in COPD

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A Phone-a-Friend CME Series – Volume 2

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