Primary Biliary Cholangitis
A High-Yield Guide to PBC Management in the Era of PPAR Agonists
Primary biliary cholangitis: epidemiology, prognosis, and treatment.
Trivella J, et al. Hepatol Commun. 2023;7(6):e0179.
Extrahepatic manifestations of primary biliary cholangitis.
Chalifoux SL, et al. Gut Liver. 2017;11(6):771-780.
Definition and management of patients with primary biliary cholangitis and an incomplete response to therapy.
Montano-Loza AJ, Corpechot C. Clin Gastroenterol Hepatol. 2021;19(11):2241-2251.e1.
Primary biliary cholangitis.
Pandit S, Hrishikesh S. In: StatPearls [Internet]. StatPearls Publishing; 2024.
Optimizing therapy in primary biliary cholangitis: alkaline phosphatase at six months identifies one-year non-responders and predicts survival.
Murillo Perez CF, et al; Global PBC Study Group. Liver Int. 2023;43(7):1497-1506.
New treatment paradigms in primary biliary cholassngitis.
Levy C, et al. Clin Gastroenterol Hepatol. 2023;21(8):2076-2087.
Increasing prevalence of primary biliary cholangitis and reduced mortality with treatment.
Lu M, et al. Clin Gastroenterol Hepatol. 2018;16(8):1342-1350.e1.
Critical shortfalls in the management of PBC: Results of a UK-wide, population-based evaluation of care delivery.
Abbas N, et al. JHEP Rep. 2023;6(1):100931.
Levels of alkaline phosphatase and bilirubin are surrogate end points of outcomes of patients with primary biliary cirrhosis: an international follow-up study.
Lammers WJ, et al. Gastroenterology. 2014;147(6):1338-1349.e5;quiz e15.
Efficacy and safety of elafibranor in primary biliary cholangitis.
Kowdley KV, et al. N Engl J Med. 2024;390(9):795-805.
A phase 3 trial of seladelpar in primary biliary cholangitis.
Hirschfield GM, et al. N Engl J Med. 2024;390(9):783-794.
GUIDELINES
Primary biliary cholangitis: 2018 practice guidance from the American Association for the Study of Liver Diseases.
Lindor KD, et al. Hepatology. 2019;69(1):394-419.
EASL clinical practice guidelines: the diagnosis and management of patients with primary biliary cholangitis.
European Association for the Study of the Liver. J Hepatol. 2017;67(1):145-172.
Guidelines on the diagnosis and management of primary biliary cholangitis (2021).
You H, et al. J Clin Transl Hepatol. 2023;11(3):736-746.
CLINICAL RESOURCES
American Association for the Study of Liver Disease (AASLD)
AASLD, founded in 1950, is a leading organization of scientists and health care professionals committed to preventing and curing liver disease.
European Association for the Study of the Liver (EASL)
EASL, founded in 1966, is a medical association dedicated to pursuing excellence in liver research, to the clinical practice of liver disorders, and to providing education to all those interested in hepatology. As of 2024, EASL serves 7,000 members from 112 countries.
PATIENT RESOURCES AND ADVOCACY ORGANIZATIONS
PBCers Organization
The PBCers Organization is an online and in-person support group for people with PBC, care partners, and health care team members.
PBC Foundation
The PBC Foundation is a UK-based charity founded on the principles of providing PBC patients, their families, and friends with accurate, up-to-date information.
American Liver Foundation
ALF was created in 1976 by the AASLD to promote education, advocacy, support services, and research for the prevention, treatment, and cure of liver disease.
Primary Biliary Cholangitis
A High-Yield Guide to PBC Management in the Era of PPAR Agonists
| Faculty: | Nancy S. Reau, MD |
| Release: | 01/17/2025 |
| Expiration: | 01/17/2026 |
