Updates on Chronic Rhinosinusitis with Nasal Polyps
Evolving Best Practices for Patient Management
Clinical Practice Guidelines
American Thoracic Society —An official ATS clinical practice guideline: interpretation of exhaled nitric oxide levels (FENO) for clinical applications.
Dweik RA, et al. Am J Respir Crit Care Med. 2011;184(5):602-615.
International Consensus Statement on Allergy and Rhinology: Rhinosinusitis.
Orlandi RR, et al. Int Forum Allergy Rhinol. 2016;6(suppl 1):S22-S209.
American Academy of Otolaryngology-Head and Neck Surgery—Clinical practice guideline (update): adult sinusitis.
Rosenfeld RM, et al. Otolaryngol Head Neck Surg. 2015;152(suppl 2):S1-S39.
EUFOREA consensus on biologics for CRSwNP with or without asthma.
Fokkens WJ, et al. Allergy. 2019;74(12):2312-2319.
Chronic rhinosinusitis with nasal polyps.
Hopkins C. N Engl J Med. 2019;381(1):55-63.
Patient Resources
Asthma and Allergy Foundation of America (AAFA)
AAFA is dedicated to improving the quality of life for people with asthma and allergic diseases including nasal polyps through education, advocacy, and research.
American Academy of Asthma, Allergy, and Immunology (AAAAI)
AAAAI is dedicated to the advancement of the knowledge and practice of allergy, asthma and immunology for optimal patient care.
Suggested Readings
Efficacy and safety of dupilumab in patients with severe chronic rhinosinusitis with nasal polyps (LIBERTY NP SINUS-24 and LIBERTY NP SINUS-52): results from two multicentre, randomised, double-blind, placebo-controlled, parallel-group phase 3 trials.
Bachert C, et al. Lancet. 2019;394(10209):1638-1650.
Effect of subcutaneous dupilumab on nasal polyp burden in patients with chronic sinusitis and nasal polyposis: a randomized clinical trial.
Bachert C, et al. JAMA. 2016;315(5):469-479.
Efficacy and safety of omalizumab in nasal polyposis: 2 randomized phase 3 trials.
Gevaert P, et al. J Allergy Clin Immunol. 2020;S0091-6749(20)30752-1. [E-pub ahead of print.]
Prevalence of chronic rhinosinusitis in the general population based on sinus radiology and symptomatology.
Dietz de Loos D, et al. J Allergy Clin Immunol. 2019;143(3):1207-1214.
Cost burden and resource utilization in patients with chronic rhinosinusitis and nasal polyps.
Bhattacharyya N, et al. Laryngoscope. 2019:129(9):1969-1975.
Endotypes and phenotypes of chronic rhinosinusitis: a PRACTALL document of the European Academy of Allergy and Clinical Immunology and the American Academy of Allergy, Asthma & Immunology.
Akdis CA, et al. J Allergy Clin Immunol. 2013;131(6):1479-1490.
Clinical research needs for the management of chronic rhinosinusitis with nasal polyps in the new era of biologics: a National Institute of Allergy and Infectious Diseases workshop.
Naclerio R, et al. J Allergy Clin Immunol Pract. 2020;8(5):1532-1549.
Biologics for chronic rhinosinusitis with nasal polyps.
Bachert C et al. Allergy Clin Immunol. 2020 ;145(3):725-739.
A phase 3 trial of mometasone furoate sinus implants for chronic sinusitis with recurrent nasal polyps.
Kern RC, et al. Int Forum Allergy Rhinol. 2018;8(4):471-481.
NAVIGATE II: randomized, double-blind trial of the exhalation delivery system with fluticasone for nasal polyposis.
Leopold DA, et al. J Allergy Clin Immunol. 2019;143(1):126-134.
Current trends in topical therapies for chronic rhinosinusitis: update and literature review.
Varshney R, Lee JT. Expert Opin Drug Deliv. 2017;14(2):257-271.
Efficacy of fluticasone exhalation delivery system in the management of chronic rhinosinusitis: what is the evidence?
Kuan EC, et al. Int Forum Allergy Rhinol. 2019;9(S1):S16-S21.
Evolving Best Practices for Patient Management
Relevant Resources
Differential Diagnosis and Comprehensive Management Strategies
Optimizing Maintenance Therapy Across Healthcare Settings
Improving Outcomes for Patients with COPD
Collaborative Approaches to Guideline-Concordant Patient Care
New Strategies for Individualizing Long-term Care
A New Era in Precision Medicine
Evolving Best Practices to Optimize Outcomes
Consensus and Controversies on the Road to Precision Medicine
Ongoing Monitoring, Pulmonary Rehabilitation, and Individualized Care
Debates and Discussions About Personalizing Patient Management
Differential Diagnosis, Multidisciplinary Management, and Patient Engagement
From Guideline Recommendations to Daily Clinical Decision-Making
Improving Patient Outcomes Through Shared Clinical Decision Making
Improving Patient Outcomes Through Shared Clinical Decision Making
Digging Deep on Shared Decision-Making
Clinical Resource Center
A Case-Based Conversation on Managing Asthma and Chronic Rhinosinusitis With Nasal Polyposis
The Clinical and Utilization Benefits of Exacerbation Prevention
Mechanistic Insights and Emerging Treatment Options
A Focus on Exacerbation Prevention
Best Practices for Primary Care
Shared Decision-making in the Era of Biologics
New Pathways to Patient Management
From Comprehensive Patient Evaluations to Individualized Evidence-based Care
Preventing COPD Exacerbations to Improve Outcomes
A Whole Patient Case Series
Debates and Discussions about Monoclonal Antibody Therapies
An Update on Monoclonal Antibody Therapies
New Avenues to the Management of Severe Asthma
Evolving Best Practices for Pediatric Patients
Interdisciplinary Strategies for Adult and Pediatric Patients
Interdisciplinary Management of Eosinophilic Esophagitis and Hereditary Angioedema
Reducing LDL-C and a Lifetime of Cardiovascular Risk
A Multidisciplinary Look at Early Diagnosis and Management
Finding the Path in Chronic Rhinosinusitis with Nasal Polyps
Recent Developments in Anti-SARS-CoV-2 Monoclonal Antibodies for Treatment
Best Practices for Diagnosis and Management
An Update on Best Practices
New Avenues to Pre-Exposure Prophylaxis
New Pathways to Optimize Patient Outcomes
Debates and Discussions About New Upstream Treatment Avenues
A Case-Based Update on Pediatric Patients
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