Meeting slides
Suggested Readings

Universal cancer screening: revolutionary, rational and realizable.

Ahlquist DA. NPJ Precis Oncol. 2018;2:23.

Cell-free DNA analysis in current cancer clinical trials: a review.

Cisneros-Villanueva M, et al. Br J Cancer. 2022;126(3):391-400.

Projected reductions in absolute cancer–related deaths from diagnosing cancers before metastasis, 2006–2015.

Clarke CA, et al. Cancer Epidemiol Biomarkers Prev. 2020;29(5):895-902.

Circulating tumor DNA (ctDNA) as a pan-cancer screening test: is it finally on the horizon?

Duffy MJ, et al. Clin Chem Lab Med. 2021;59(8):1353-1361.

Multi-cancer early detection: the new frontier in cancer early detection.

Guerra CE, et al. Annu Rev Med. 2024;75:67-81.

New genomic technologies for multi-cancer early detection: rethinking the scope of cancer screening.

Hackshaw A, et al. Cancer Cell. 2022;40(2):109-113.

Sensitive and specific multi-cancer detection and localization using methylation signatures in cell-free DNA.

Liu MC, et al. Ann Oncol. 2020;31(6):745-759.

Multicancer screening: one size does not fit all.

Putcha G, et al. JCO Precis Oncol. 2021:574-576.

Modelled mortality benefits of multi-cancer early detection screening in England.

Sasieni P, et al. Br J Cancer. 2023;129(1):72-80.

Blood-based tests for multicancer early detection (PATHFINDER): a prospective cohort study.

Schrag D, et al. Lancet. 2023;402(10409):1251-1260.

Sensitivity, specificity, and predictive values: foundations, pliabilities, and pitfalls in research and practice.

Trevethan R. Front Public Health. 2017;5:307.

Linked Resources

MCED Screening Quick Reference Guide

This downloadable and printable resource can be utilized in the office to facilitate communication with patients about using MCED screening and as a provider quick reference tool. This reference guide is double-sided: one side describes the benefits of early cancer detection and the MCED testing process for patients, and the other side details MCED testing workflow and follow-up care pathways for the most common “cancer detected” results.

Related CME Activities

Hot Topics in Blood-Based Cancer Screening

Volume 2: Updates from Spring 2024 Oncology Conferences                                         

Not A Moment Too Soon

Incorporating Multi-Cancer Early Detection (MCED) Testing Into Primary Care Practice

Multi-Cancer Early Detection

Incorporating Blood-Based Screening Tools into Primary Care Practice

Guidelines

Published A and B Recommendations for Cancer.

US Preventive Services Task Force. 

Breast Cancer: Screening. Final Recommendation Statement.

US Preventive Services Task Force. April 30, 2024

Prostate Cancer: Screening. Final Recommendation Statement.

US Preventive Services Task Force. May 8, 2018

White paper on Multicancer Early Detection (MCED) Screening Guidance: A Recommended Care Pathway for Clinical Use of MCED Tests.

Multicancer Early Detection Consortium. June 27, 2023

Clinician Resources

Prevent Cancer Foundation

Multi-cancer early detection.

Surveillance, Epidemiology, and End Results (SEER) *Explorer

An interactive website for SEER cancer statistics. Surveillance Research Program, National Cancer Institute, Division of Cancer Control and Population Sciences.

Galleri Test Website

Menlo Park, CA: Grail LLC.

Related activities
Webcast 
1.50 AMA PRA

Testing Your Skills in Blood-Based Multi-Cancer Screening

A CME Jeopardy™ Event

Faculty: Mark D. Gomez, MD; Gautum Agarwal, MD; Mylynda B. Massart, MD, PhD
Release: 09/27/2024
Expiration: 11/06/2024
Webcast 
1.00 AMA PRA

Testing Your Skills in Blood-Based Multi-Cancer Screening

A CME Jeopardy Activity

Faculty: Mark D. Gomez, MD; Gautum Agarwal, MD; Mylynda B. Massart, MD, PhD
Release: 11/15/2024
Expiration: 11/15/2025