Towards precision medicine in non-alcoholic fatty liver disease.
Francque SM. Rev Endocr Metab Disord. 2023;24(5):885-899.
A phase 3, randomized, controlled trial of resmetirom in NASH with liver fibrosis.
Harrison SA, Bedossa P, Guy CD, et al. N Engl J Med. 2024;390(6):497-509.
Tirzepatide once weekly for the treatment of obesity.
Jastreboff AM, Aronne LJ, Ahmad NN, et al. N Engl J Med. 2022;387(3):205-216.
Karim G, Bansal MB. Resmetirom: an orally administered, small molecule, liver-directed, β-selective THR agonist for the treatment of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis. touchREV Endocrinol. 2023;19(1):60-70.
Bariatric surgery provides long-term resolution of nonalcoholic steatohepatitis and regression of fibrosis.
Lassailly G, Caiazzo R, Ntandja-Wandji LC, et al. Gastroenterology. 2020;159(4):1290-1301.e1295.
Semaglutide 2.4 mg once weekly in patients with non-alcoholic steatohepatitis-related cirrhosis: a randomised, placebo-controlled phase 2 trial.
Loomba R, Abdelmalek MF, Armstrong MJ, et al. Lancet Gastroenterol Hepatol. 2023;8(6):511-522.
Tirzepatide for metabolic dysfunction-associated steatohepatitis with liver fibrosis.
Loomba R, Hartman ML, Lawitz EJ, et al. N Engl J Med. 2024;391(4):299-310.
A placebo-controlled trial of subcutaneous semaglutide in nonalcoholic steatohepatitis.
Newsome PN, Buchholtz K, Cusi K, et al. N Engl J Med. 2021;384(12):1113-1124.
Expert panel recommendations: practical clinical applications for initiating and monitoring resmetirom in patients with MASH/NASH and moderate to noncirrhotic advanced fibrosis.
Noureddin M, Charlton MR, Harrison SA, et al. Clin Gastroenterol Hepatol. 2024:S1542-3565(24)00667-0.
Monitoring disease progression in metabolic dysfunction-associated steatotic liver disease.
Noureddin N, Copur-Dahi N, Loomba R. Aliment Pharmacol Ther. 2024;59(suppl 1):S41-S51.
A randomized, controlled trial of 3.0 mg of liraglutide in weight management.
Pi-Sunyer X, Astrup A, Fujioka K, et al. N Engl J Med. 2015;373(1):11-22.
A multisociety Delphi consensus statement on new fatty liver disease nomenclature.
Rinella ME, Lazarus JV, Ratziu V, et al. Hepatology. 2023;78(6):1966-1986.
Once-weekly semaglutide in adults with overweight or obesity.
Wilding JPH, Batterham RL, Calanna S, et al. N Engl J Med. 2021;384(11):989-1002.
The global epidemiology of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis among patients with type 2 diabetes.
Younossi ZM, Golabi P, Price JK, et al. Clin Gastroenterol Hepatol. 2024;22(10):1999-2010.e1998.
Clinical Practice Guidelines
AASLD Practice Guidance on the clinical assessment and management of nonalcoholic fatty liver disease.
Rinella ME, Neuschwander-Tetri BA, Siddiqui MS, et al. Hepatology. 2023;77(5):1797-1835.
AASLD Practice Guideline on imaging-based non-invasive liver disease assessments of hepatic fibrosis and steatosis.
Sterling RK, Duarte-Rojo A, Patel K, et al. Hepatology. 2024. [Epub ahead of print]
AASLD Practice Guidance on prevention, diagnosis, and treatment of hepatocellular carcinoma.
Singal AG, Llovet JM, Yarchoan M, et al. Hepatology. 2023;78(6):1922-1965.
Clinical Resources
Fibrosis-4 (FIB-4) index for liver fibrosis.
Resmetirom prescribing information.
US Food and Drug Administration.
What’s New in MASH: Strengthening Your Diagnostic and Management Muscles
A CME Circuit Training™ Activity
Faculty: | Sonal Kumar, MD, MPH; Naim Alkhouri, MD, FAASLD |
Release: | 11/01/2024 |
Expiration: | 11/01/2025 |