A phase 3, randomized, controlled trial of resmetirom in NASH with liver fibrosis.
Harrison SA, Bedossa P, Guy CD, et al. N Engl J Med. 2024;390(6):497-509.
Tirzepatide once weekly for the treatment of obesity.
Jastreboff AM, Aronne LJ, Ahmad NN, et al. N Engl J Med. 2022;387(3):205-216.
Bariatric surgery provides long-term resolution of nonalcoholic steatohepatitis and regression of fibrosis.
Lassailly G, Caiazzo R, Ntandja-Wandji LC, et al. Gastroenterology. 2020;159(4):1290-1301.e1295.
Tirzepatide for metabolic dysfunction-associated steatohepatitis with liver fibrosis.
Loomba R, Hartman ML, Lawitz EJ, et al. N Engl J Med. 2024;391(4):299-310.
The contribution of genetics and epigenetics to MAFLD susceptibility.
Moretti V, Romeo S, Valenti L. Hepatol Int. 2024;18(suppl 2):848-860.
Phase 3 ESSENCE trial: semaglutide in metabolic dysfunction-associated steatohepatitis (MASH)
Newsome PN, Sanyal A, Kliers I, et al. American Association for the Study of Liver Diseases annual meeting. San Diego, California; November 15-29, 2024. Abstract 5018.
Expert panel recommendations: practical clinical applications for initiating and monitoring resmetirom in patients with MASH/NASH and moderate to noncirrhotic advanced fibrosis.
Noureddin M, Charlton MR, Harrison SA, et al. Clin Gastroenterol Hepatol. 2024:S1542-3565(24)00667-0.
Monitoring disease progression in metabolic dysfunction-associated steatotic liver disease.
Noureddin N, Copur-Dahi N, Loomba R. Aliment Pharmacol Ther. 2024;59(suppl 1):S41-S51.
A multisociety Delphi consensus statement on new fatty liver disease nomenclature.
Rinella ME, Lazarus JV, Ratziu V, et al. Hepatology. 2023;78(6):1966-1986.
Is digital pathology the new standard in MASH trials?
Wang Y, Wong VW-S. Hepatology. 2024. [Epub ahead of print]
Once-weekly semaglutide in adults with overweight or obesity.
Wilding JPH, Batterham RL, Calanna S, et al. N Engl J Med. 2021;384(11):989-1002.
Clinical Practice Guidelines
Resmetirom therapy for metabolic dysfunction-associated steatotic liver disease: October 2024 updates to AASLD Practice Guidance.
Chen VL, Morgan TR, Rotman Y, et al. Hepatology. 2025;81(1):312-320.
AASLD Practice Guidance on the clinical assessment and management of nonalcoholic fatty liver disease.
Rinella ME, Neuschwander-Tetri BA, Siddiqui MS, et al. Hepatology. 2023;77(5):1797-1835.
AASLD Practice Guideline on imaging-based non-invasive liver disease assessments of hepatic fibrosis and steatosis.
Sterling RK, Duarte-Rojo A, Patel K, et al. Hepatology. 2024. [Epub ahead of print]
AASLD Practice Guidance on prevention, diagnosis, and treatment of hepatocellular carcinoma.
Singal AG, Llovet JM, Yarchoan M, et al. Hepatology. 2023;78(6):1922-1965.
Clinical Resources
Fibrosis-4 (FIB-4) index for liver fibrosis.
Resmetirom prescribing information.
US Food and Drug Administration.
Comprehensive Case Challenges in MASH
Diagnosing, Staging, and Treating Patients in an Advancing Field
Faculty: | Rohit Loomba, MD, MHSc; Vlad Ratziu, MD |
Release: | 01/10/2025 |
Expiration: | 02/10/2025 |