The Role of Epithelial Cytokine Signaling in CRSwNP
Diagnosis and management of chronic rhinosinusitis.
Chin CJ, et al. CMAJ. 2025;197(6):E148-E154.
The unified airway hypothesis: evidence from specific intervention with anti-IL-5 biologic therapy.
Bachert C, et al. J Allergy Clin Immunol Pract. 2023;11(9):2630-2641.
The advance on pathophysiological mechanisms of type 2 chronic rhinosinusitis with nasal polyposis.
Yang C, et al. Front Allergy. 2025;6:1599797.
Quality of life in type 2 and non-type 2 endotypes in chronic rhinosinusitis with nasal polyps: A prospective trial.
Bogaert S, et al. Clin Transl Allergy. 2025;15(6):e70070.
The Therapeutic Role of Biologics in Chronic Rhinosinusitis with Nasal Polyps (CRSwNP): A Review of the Current Evidence.
Chen W, et al. Ther Clin Risk Manag. 2026;22:586959.
Tezepelumab in adults with severe chronic rhinosinusitis with nasal polyps.
Lipworth BJ, et al. N Engl J Med. 2025;392(12):1178-1188.
Use of tezepelumab for chronic rhinosinusitis with nasal polyps by eosinophilic endotype WAYPOINT post-hoc analysis.
Fujieda S, et al. Ann Allergy Asthma Immunol. 2026:S1081-1206(26)00352-2.
Mepolizumab for chronic rhinosinusitis with nasal polyps (SYNAPSE): a randomised, double-blind, placebo-controlled, phase 3 trial.
Han JK, et al. Lancet Respir Med. 2021;9(10):1141-1153.
Efficacy and safety of omalizumab in nasal polyposis: 2 randomized phase 3 trials.
Gevaert P, et al. J Allergy Clin Immunol. 2020;146(3):595-605.
Efficacy and safety of dupilumab in patients with severe chronic rhinosinusitis with nasal polyps (LIBERTY NP SINUS-24 and LIBERTY NP SINUS-52): results from two multicentre, randomised, double-blind, placebo-controlled, parallel-group phase 3 trials.
Bachert C, et al. Lancet. 2019;394(10209):1638-1650
Assessing adequacy of surgical extent in CRSwNP: The Completion of Surgery Index
Workman AD, et al. Int Forum Allergy Rhinol. 2025;15(1):9-17.
Consensus criteria for chronic rhinosinusitis disease control: an international Delphi study.
Sedaghat AR, et al. Rhinology. 2023;61(6):519-530.
AAO-HNSF 2026 Annual Meeting.
Online program.
Clinical Practice Guidelines
EPOS/EUFOREA update on indication and evaluation of biologics in chronic rhinosinusitis with nasal polyps 2023.
Fokkens WJ, et al. Rhinology. 2023;61(3):194-202.
European Position Paper on Rhinosinusitis and Nasal Polyps 2020.
Fokkens WJ, et al. Rhinology. 2020;58(Suppl S29):1-464.
Patient-Reported Outcomes Measures (PROM)
Sino-Nasal Outcome Test-22 (SNOT-22)
Evaluation of the Patient Global Impression of Symptom Severity (PGISS) Score as a Subjective and Objective Measure of Disease Activity in Chronic Rhinosinusitis.
Lim Set al. Am J Rhinol Allergy. 2025;39(2):128-135.
Patient Advocacy Organizations and Resources
American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS)
With approximately 13,000 members, the AAO-HNS is one of the world’s largest organizations for clinicians specializing in the care of patients’ ears, nose, and throat, and strives to promote high-quality patient care through education, research, and public health policy.
American Academy of Allergy, Asthma, & Immunology (AAAAI)
The AAAAI is the leading membership organization of more than 7100 allergists/immunologists and patients' trusted resource for allergies, asthma and immune deficiency disorders.
American College of Allergy, Asthma, & Immunology (ACAAI)
The ACAAI fosters a culture of collaboration and congeniality in which members work toward the common goals of patient care, education, advocacy, and research.
American Partnership for Eosinophilic Disorders (APFED)
APFED is a nonprofit organization dedicated to improving the lives of those impacted by eosinophilic disorders by promoting awareness, advancing research, and supporting advocacy and other initiatives.
Asthma and Allergy Foundation of America (AAFA)
The AAFA is a the leading nonprofit patient organization for patients with airway diseases like asthma and allergies, and strives to improve patients’ quality of life through support, advocacy, education, and research.
Epithelial Cytokines in the Spotlight
Focusing on Chronic Rhinosinusitis With Nasal Polyps
| Faculty: | Joseph K. Han, MD, FARS, FAAOA; Rohit K. Katial, MD; Stella Lee, MD |
| Release: | 10/18/2026 |
| Expiration: | 11/18/2026 |
