CA Part 2: CAR T-Cell Therapy in NHL Subtypes

Target Audience

This educational activity will address identified knowledge and practice gaps among community hematologists and oncologists who refer patients with B-cell non-Hodgkin lymphoma (NHL) to CAR T-cell treatment centers.

Learning Objectives

Upon completion of this activity, participants should be better able to:

• Recognize patients with NHL early in their disease course who may be appropriate candidates for referral to CAR T-cell therapy
• Evaluate the efficacy and safety profiles of FDA-approved CAR T-cell constructs for the treatment of NHL
• Outline best practices for monitoring, mitigating, and managing both short- and long-term adverse events associated with CAR T-cell therapy
• Implement strategies to enhance multidisciplinary collaboration between CAR T-cell centers and community practices to address barriers in referral and care delivery
• Employ patient-centered communication strategies to enhance understanding and shared decision making regarding the benefits and risks of CAR T-cell therapy

Program Overview

During CAR T-Cell Therapy in Non-Hodgkins Lymphoma (NHL): A Case-Based Workshop, the lessons from Workshop 1 will be reinforced through a series of patient-case scenarios. By covering a series of patient cases across the NHL spectrum, expert faculty will engage learners in discussions that cover patient selection and referral for CAR T-cell therapy, the coordination of care between community practices and CAR T-cell centers, and the identification and mitigation of adverse events following treatment. In addition, learners who complete the program will develop tools to employ in shared decision-making conversations with patients regarding their care, and better understand the importance of multidisciplinary collaboration and continued communication between treatment centers and community practice. 

Agenda

• Introduction
• Brief Review of CAR T-Cell Therapy for NHLs
• Case 1: A Patient With Diffuse Large B-cell Lymphoma (DLBCL): Exploring CAR T-Cell Therapy
• Case 2: A Patient With Follicular Lymphoma (FL) or Marginal Zone Lymphoma (MZL): Exploring CAR T-Cell Therapy in Indolent NHL
• Case 3: A Patient With Chronic Lymphocytic Leukemia (CLL): Recognizing and Mitigating Immune Effector Cell-Associated Neurotoxicity Syndrome (ICAN) and Cytokine Release Syndrome (CRS)
• Case 4: A Patient With Mantle Cell Lymphoma (MCL): Managing Potential Longer-Term AEs
• Concluding Comments 

Physician Accreditation Statement

Integritas Communications is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Physician Credit Designation

Integritas designates this live activity for a maximum of 1.0 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Instructions to Receive Credit

In order to receive credit for this activity, the participant must complete the pretest, pass the posttest with a 70% score or higher, and submit an evaluation form.

Fee Information

There is no fee for this activity.

Disclosures of Conflicts of Interest

Integritas adheres to the policies and guidelines, including the Standards for Integrity and Independence in Accredited CE, set forth to providers by the Accreditation Council for Continuing Medical Education (ACCME) and all other professional organizations, as applicable, stating those activities where continuing education credits are awarded must be balanced, independent, objective, and scientifically rigorous. All persons in a position to control the content of an accredited continuing education program provided by Integritas are required to disclose all financial relationships with any ineligible company within the past 24 months to Integritas. All financial relationships reported are identified as relevant and mitigated by Integritas in accordance with the Standards for Integrity and Independence in Accredited CE in advance of delivery of the activity to learners. The content of this activity was vetted by Integritas to assure objectivity and that the activity is free of commercial bias.  

All relevant financial relationships have been mitigated. 

The faculty have the following relevant financial relationships with ineligible companies:

Ayad Hamdan, MD: TBD

The Integritas planners and managers have reported no relevant financial relationships with ineligible companies:

Disclosure of Unlabeled Use

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the US Food and Drug Administration. Integritas does not recommend the use of any agent outside of the labeled indications.  

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of any organization associated with this activity. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

Disclaimer

Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed in this activity should not be used by clinicians without evaluation of patient conditions and possible contraindications or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.

Contact Information 

For information about this activity, please contact us at info@exchangecme.com